Technische Universität Wien
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Novel Sensing Concepts for Mid-IR Laser Spectroscopy (H2020 PhD Thesis)

Background and Motivation

Mid-IR lasers have turned into a key enabling technology for highly integrated, highly sensitive chemical sensors. The Lendl group has been at the forefront of this development from the beginning.

 

Scope of the work


You will be working in the Lendl group at TU Wien as part of the Horizon 2020 EU project “Hydroptics”. Together with an international, interdisciplinary consortium of industrial stake holders, laser physicists, chemists, physicists, instrument developers, chemical and process engineers, we are working on the next generation of mid-IR sensors for industrial applications. Hydroptics aims to develop on-line sensor technology for measuring particles, residual oil as well as corrosion inhibitors in industrial water streams of the oil industry. The sensing schemes to be explored in the Lendl laboratory shall comprise chemically functionalized mesoporous sensing layers attached to mid-IR waveguides and implemented in novel optical set-ups that make use of the unique properties of mid-IR lasers and mid-IR frequency combs.

Your thesis will encompass the development, implementation and testing of mesoporous sensing layers for the real-world applications at OMV exploration and production GmbH. Within “Hydroptics” you will also network and interact with academic and industrial partners from Austria and across Europe. As with any doctoral thesis, here, a great deal of self-motivated, creative work is expected. The Lendl group has a positive, collaborative work environment. We are a team of experienced graduate and post graduate students (physicists, chemists, chemical engineers, biomedical engineers) and are happy to lend a hand. Attendance of international scientific conferences and publishing of scientific articles is strongly encouraged.

Requirements

• Masters in Chemistry, Physics, Electrical Engineering or Biomedical Engineering or similar
• Interest in instrumental analysis, chemical synthesis, instrument development and creative problem solving
• Prior experience in programming (Python, Matlab), electronics, optics, spectroscopy is advantageous but not required
• Fluency in English is required

Salary: 30 hours per week PhD position

There is no fixed deadline for applications, but we expect all successful applications will have arrived at the beginning of April 2020.

 

Contact


Georg Ramer
Andreas Schwaighofer
Prof. Bernhard Lendl

Time-Resolved FTIR-Spectroscopy for Analysis of Refolding Kinetics of Proteins (Master Thesis)

Background and Motivation

FTIR spectroscopy is an excellent method for studying protein secondary structure. By applying dedicated experimental techniques such as rapid-scan or step-scan spectroscopy, time-resolved spectra acquisition can be obtained with millisecond and nanosecond time resolution. For time-resolved spectroscopy of non-reproducible experiments, the rapid scan technique is employed. Here, this time- resolved technique will be applied to study protein structure change of a model protein after temperature jump excitation for analysis of the refolding kinetics in the millisecond time range.

Scope of the work

The student will be working in the Lendl lab at TU Wien together with a multi-disciplinary team of Master and PhD students as well as PostDocs. The work consists of setting up a temperature-jump experiment for studying conformational changes in a protein model system after thermal perturbation by rapid scan FTIR spectroscopy.
The thesis combines tasks in FTIR spectroscopy, liquid handling and optimizing experiment design. Students interested in extending their skills in these fields and in creative experimenting are encouraged to get in contact with us!

Requirements

  • Bachelor studies in Physics, Chemistry or equivalent

  • Interest in instrumental analysis, spectroscopy, protein dynamics

Contact

Dr. Andreas Schwaighofer
andreas.schwaighofer@tuwien.ac.at
Prof. Bernhard Lendl
bernhard.lendl@tuwien.ac.at